What Does Synephrine Do In Pre-workout?

Medically reviewed by Dr Dimitar Marinov
What does Synephrine do in Pre-workout?

Having a fast metabolism is the goal. Optimising your diet and keeping an active lifestyle acts with your metabolism to increase your energy, improve your sleep and reduce excess fat. Unfortunately, as we get older, our metabolisms take a hit and start to slow down.

That’s where Synephrine comes in. Let’s explore just what synephrine is, from its positive effects to its side effects.

What Is Synephrine?

Synephrine is an alkaloid used in certain products that can help increase resting metabolism. It can allegedly have appetite-suppressing properties and promotes weight loss through the process of enhanced thermogenesis without negative effects on the cardiovascular system.

This is a natural chemical, structurally similar to catecholamines (adrenaline and noradrenaline), that cause the breakdown of fat cells. Synephrine is a central nervous system stimulant with effects very similar to ephedrine but with fewer detrimental effects.

Some studies have shown that Synephrine can increase fat oxidation. When ingested in a pre-workout, it releases adrenaline and norepinephrine and triggers beta-3 receptors that are directly responsible for lipolysis (the combustion of fatty acids). This is why you’ll find this bitter orange extract in many thermogenic, as it has been proven to be beneficial for muscle endurance both alone and when combined with caffeine.

What Are The Benefits Of Synephrine In Pre-workout Supplements?

Benefits Of Synephrine In Pre-workout Supplements

Fat loss

Synephrine is known for reducing the percentage of fat. This alkaloid relates to this by:

  • Increasing energy
  • Increasing metabolism
  • Reducing appetite
  • Having a thermogenic effect

Homeopathic remedy

Synephrine can be used as a more natural option in a range of different conditions, including:

  • Gastrointestinal disorders
  • Nervousness
  • Insomnia
  • Gout
  • Sore throat
  • Obesity

What Is The Recommended Dosage Of Synephrine?

The recommended dosage of Synephrine is between 30-50mg. When understanding the proper dosage of Synephrine, always check the supplement’s label.

If it is labelled “Bitter Orange Extract”, you should check what it is standardised for. 100mg of Bitter Orange Extract, which is standardised for 25% Synephrine, means that there is 25mg of Synephrine. The key is finding a dosage that increases your resting metabolic rate without risking an increase in your blood pressure.

A recent study showed that 50mg of Synephrine will actually increase your resting metabolic rate without increasing your blood pressure. 

How Should You Take Synephrine?

You can typically find synephrine in dietary supplements that contain Bitter Orange or in lipolytic formulas with other ingredients (like caffeine) to create a synergising effect. The average dose is 20mg, which can be taken approximately two to three times daily.

When using synephrine, it’s important to ensure you’re following a balanced diet, as it will help, but only to a certain extent.

Can you pair synephrine and caffeine?

Can you pair synephrine and caffeine?

Yes. Caffeine is the most popular stimulant used throughout the whole world, mainly because of its many benefits, but how does it pair with synephrine? Well, it’s basically a win-win situation when you put these two ingredients together.

This combination is completely safe to use and is quite a common pairing. In fact, they can lead to better resting metabolic rates together, and this may lead to improved weight loss.

When Should You Take Synephrine?

The best time to take Synephrine to optimise your weight-loss journey or see an improvement in your energy and mental focus is before your training sessions.

Where Can I Buy Pre-Workout Supplements With Synephrine In?

Synephrine-containing supplements are a great way to improve body weight control, and they can be found in many great pre-workouts. You can find some of these in great flavours here at Power Supps.

What Are The Potential Side Effects Of Synephrine Supplementation?

Synephrine by itself is not known to have many adverse effects, but for some people, if it’s combined with caffeine, it could increase the risk of :

  • High blood pressure
  • Headaches
  • Cluster headaches
  • Heart attack
  • Fainting
  • Strokes
  • Migraines

Final Thoughts On Synephrine Do in Pre-workout Supplements

Using weight loss supplements, like pre-workout, with Synephrine is a brilliant way to give your metabolism the boost that it needs to increase whole-body fat oxidation and elevate energy levels. It’s incredibly effective when combined with caffeine and should improve your overall exercise performance and basal metabolic rate.

Always consult with a medical professional if you have any health concerns, such as cardiovascular disease, to decide if this is right for you.

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