What Does Agmatine Sulfate Do In Pre Workout?

Medically reviewed by Dr Dimitar Marinov
What Does Agmatine Sulfate Do In Pre Workout?

Agmatine sulfate is becoming an increasingly popular addition to pre workouts. But what exactly is agmatine sulfate, and what does it bring to your workout?

That’s what we’ll be looking at here. We’ll explore the benefits and side effects of agmatine sulfate, look at dosage guidelines, and explain in simple terms what it is.

What Is Agmatine Sulfate?

Agmatine Sulfate

Agmatine sulfate is derived from the amino acid L-arginine, naturally produced by the body and stored in the brain. Its function is to shield the brain from toxins, protect against pain, and fight off depression.

It is also believed to enhance focus, performance, mood, and cognitive function, and this is why it’s started making its way into pre workout supplements.

What Are The Benefits Of Agmatine Sulfate In Pre Workout Supplements?

Benefits Of Agmatine Sulfate In Pre Workout Supplements

There are multiple benefits of agmatine sulfate, and when paired with other ingredients used to make pre workout, it can do so much more than enhance your focus and performance. This includes:

Pain Reduction

Agmatine sulfate is capable of reducing both inflammation and neuropathic pain. This doesn’t only mean that it allows for better recovery, potentially resulting in faster muscle growth, but it also means that it can help overcome perceived pain during training.

Blood Glucose

One of the biggest benefits of agmatine sulfate is that it activates the imidazoline receptors in your body, which reduces your blood glucose levels and increases endorphin production. Increased endorphin production results in an increase in insulin sensitivity being taken into muscle tissues, potentially leading to a leaner physique.


Since agmatine sulfate’s role in the body is to shield your brain from stress, depression, and toxins, it can help to improve your focus while you train by lowering cortisol levels and providing a better overall sense of well-being.

Nitric Oxide Synthase

Agmatine sulfate also plays a key role in regulating nitric oxide synthase (NOS), which is the enzyme responsible for the production of nitric oxide. As nitric oxide improves blood flow, your muscle pumps will be way more effective and intense, and nutrient delivery to the muscle tissues will be increased.

Blood Pressure

With nitric oxide synthase being better regulated by agmatine sulfate and blood flow improving, it also has the potential to regulate blood pressure more effectively. This allows for better nutrient delivery to every cell in your body, as well as optimal muscle growth and recovery.

What Is The Recommended Dosage Of Agmatine Sulfate?

Recommended Dosage Of Agmatine Sulfate

There isn’t a standard dose recommended for agmatine sulfate, and it’s important that you follow the dosage outlined on the pre workout packaging. It should also be taken in line with your body weight and personal goals.

As a general rule, however, most people find that 1.6-6.4mg per kilogram of body weight each day is the ideal dosage to get the optimal benefits. Of course, this depends on your own tolerances, and it is best to start with a smaller dose and monitor how your body reacts before increasing to higher doses.

It’s also important that you don’t exceed 6.4mg of agmatine sulfate per kilogram of your body weight, as doing so may result in side effects.

How Should You Take Agmatine Sulfate?

You should take agmatine sulfate in the way directed on the pre workout packaging. However, it would be best to take it with food if you’re taking supplemental agmatine sulfate on its own, as this will help the body process it and allow it to get into your bloodstream faster.

When Should You Take Agmatine Sulfate?

When Should You Take Agmatine Sulfate?

There is no particular time of day recommended for taking agmatine sulfate. However, if it is incorporated into your pre workout, it would be best to take it up to half an hour before training, especially if you’re looking for increased muscle pump or extreme resistance training.

Where Can I Buy Pre Workout Supplements With Agmatine Sulfate In?

There are a couple of excellent pre workouts that have agmatine sulfate in their ingredients, which we’ve listed below. These pre workouts can be purchased from Power Supps, along with loads of other fitness and dietary supplements.

  • Ghost Legend Pre Workout
  • RedCon1 Total War
  • Purge Sports PRE V2
  • Glycerpump Syrup
  • Staunch Koala Freak 2.0
  • Axe & Sledge Hydraulic

What Are The Potential Side Effects Of Agmatine Sulfate Supplementation?

There are very few side effects associated with agmatine sulfate, with the most commonly reported being mild nausea, diarrhea, and gastrointestinal discomfort. As always, side effects are dependent on personal tolerance and dosage, and it may take some people a little fine-tuning to use agmatine sulfate without any side effects. For the most part, however, side effects are rarely reported.

Final Thoughts On Agmatine Sulfate In Pre Workout Supplements

With its ability to increase focus and performance, as well as its power in increasing nitric oxide production, it’s clear to see why agmatine sulfate is being incorporated into more and more pre workouts. It also has very few rarely-reported side effects, making it arguably one of the safer ingredients you’ll find, too. So, if you’ve been looking to start a bodybuilding supplement regimen or want a little more from your pre workout, going for something with agmatine sulfate would be a good choice.

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